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Keywords: interstitial cystitis, phytochemicals, uroprotective, inflammation, inflamed bladder tissue, painful bladder syndrome Introduction Interstitial cystitis/Painful bladder syndrome (IC/PBS) is chronic discomfort of the bladder wall, presenting with symptoms such as urinary frequency, urgency, and severe pelvic or suprapubic pain

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It is associated with poorer quality of life, reduced life expectancy, and, therefore, high rates of morbidity and mortality, and increased hospitalization costs ( Endothelial activation in CKD may be attributed to different factors: the pulsatile blood flow and disturbed shear stress ( Innate immune system alterations have been also reported in association with end-stage renal disease, aggravated by dialysis procedures